Rheo designed and built a custom weigh and dispense system for transferring potent materials in a Class II, Division 1 hazardous environment, ensuring safe, ergonomic, and compliant operation through the use of pneumatic controls and containment technologies.
At the core of the system is a Custom Material Transfer Station which integrates a pneumatic drum tipper, Mettler Toledo weighing system, and a flexible enclosure support frame into a mobile, GMP-compliant workstation. The Drum Tipper accommodates drums up to 75 kg and features a powered slide for drum positioning in the flexible enclosure. The receiving container rests on calibrated Mettler Toledo load cells, enabling precise weigh-outs of material into a split butterfly valve charge bottle or a single use bag.
The station is designed to support Rheo Flexible glovebag enclosures and includes containment ports for bag-in/bag-out operations. An additional sleeve below the table provides additional containment around the split butterfly valve system.
To maintain a controlled environment during material transfer, a manual pneumatic RheoFan is included. This unit provides slight negative pressure within the isolator and breach airflow compliant with AGS-G001-2007 standards. It features dual safe change HEPA filtration, ensuring cleanroom-level containment performance of <1 µg/m³ when used with Rheo Flexibles.
All product contact surfaces are mechanically polished to 25 µin Ra for hygienic performance, while non-contact surfaces are polished to 35 µin Ra. The system includes full documentation and is engineered for full wipe-down cleaning and safe operation in hazardous environments.
